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A randomized, double-blind, three-arm crossover pharmacokinetic study in human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg.
Researchers at the University of Washington have completed a clinical trial with 140 participants showing that orally administered NR gives a dose dependent increase in NAD+ from 250-1000 mg/day plateauing at a 2-fold increase in NAD+ at day nine.
Nicotinamide Riboside (NR) is more effective to increase NAD+ levels in your body than supplementing with straight NAD+ itself as NR can enter the cell directly without requiring a breakdown and therefore less nutrients are loss in the transferal process.
|Nicotinamide Riboside (NR) Supplement||Direct NAD+ Supplement|
|Mass||A cellular nutrient designed to permeate the cell wall with ease efficiently||A very large molecule that is unable to enter the cell directly|
|Penetration to the cells||Enter the cell directly without requiring a breakdown||Require break down to smaller pieces before passing through the cell membrane|
|Efficacy||Clinically proven effective in raising NAD+ level||The breakdown makes the process less efficient at increasing NAD+ in the cells|
|Storage in Capsule Form||Ordinary storage condition||Degrade quickly when exposed to normal light and heat|
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